Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical aim and pharmacology regarding curcumin
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin ‘s the biggest component of the portugisiska skГ¶nheter fГ¶r Г¤ktenskap new red dye out of turmeric, an Indian spruce that is extracted from the fresh new rhizome of the exotic bush Curcuma longa, and therefore is one of the Zingiberaceae members of the family. Contained in this part, we talk about the pharmacological things out of curcumin and you can talk about the molecular bases for those factors. We after that comment the fresh new demonstrated and possible clinical uses out-of curcumin. Curcumin is famous usually because the a curative broker, but the procedure away from step try detail by detail. This new pharmacological effects of curcumin appear to be the consequence of a beneficial synergism out-of networking sites off weak biochemical connections having multiple physiological plans for the interconnected signaling pathways. These types of objectives include nutrients such as for example cyclooxygenase, lipoxygenase and you will healthy protein kinases, and transcription situations particularly NF-?B, STAT and you may Nrf2. Modulation of them particles influences downstream affectors which make the antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial activities out of curcumin. This type of outcomes was basically examined when you look at the health-related products from curcumin getting soreness and you can inflammatory illness, malignant tumors, Alzheimer condition, cardio problems, and you may diabetic issues. The products purchased adjustable dosage away from curcuminwith some other frequencies and you will course, for the general conclusion you to large doses off curcumin within number of g have to obtain therapeutic outcomes. Find out more
Curcumin: Synthesis, Emerging Role during the Problems Management and you can Fitness Implications
Book Section Examples of plant-derived pharmaceuticals having get to be the attention out of persisted and you will great search and you may innovation interest have, to date, become some scarce. Immediately after years, the last 2 decades was indeed described as a good 100-bend increase in exactly how many medical posts penned annually you to is off significance towards the means to access curcumin inside the biomedicine. Read more
Construction, synthesis and physical things regarding curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some potential pharmacological consequences and will features therapeutic software in lot of situation says, given that discussed in more detail in the previous section. Although not, the possibility systematic effectiveness out of curcumin is restricted by the the physicochemical attributes of bad water solubility and you will imbalance, and therefore produce reasonable bioavailability. Prodrugs regarding curcumin promote an approach to improve of biopharmaceutical and you can pharmacokinetic features, that will make it exploitation of your pharmacological aftereffects of curcumin. Within part, we first comment the newest physicochemical and you can pharmacokinetics out of curcumin. I upcoming define the appearance of curcumin prodrugs having improved drinking water solubility and increased agents balances which are converted back into 100 % free curcumin through to bioactivation inside vivo. I emphasize current triumph in this field, that have a concentrate on the framework, synthesis and you can testing off prodrugs predicated on promoieties also proteins, fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric product instance hyaluronic acidic and you may polyethylene glycol. It chapter gets the reason behind optimisation of your own physicochemical and you may biopharmaceutical services together with physiological points out-of curcumin prodrugs, toward purpose using of them curcumin types inside logical applications. Read more